Abstract #4686
Aging in Deep Gray Matter Revealed by Diffusional Kurtosis Imaging
Nan-Jie Gong 1,2 , Chun-Sing Wong 1 , Chun-Chung Chan 3 , Lam-Ming Leung 4 , Yiu-Ching Chu 5 , and Queenie Chan 6
1
Diagnostic Radiology, The University of Hong
Kong, Hong Kong, China,
2
Radiology,
Stanford University, Stanford, CA, United States,
3
Geriatrics
& Medicine, United Christian Hospital, Hong Kong, China,
4
Psychiatry,
United Christian Hospital, Hong Kong, China,
5
Radiology,
Kwong Wah Hospital, Hong Kong, China,
6
Philips
Healthcare, Hong Kong, China
we utilised DKI method in both deep gray and white
matters of normal aging adults. The results suggested
that diffusional kurtosis can provide measurements in a
new dimension complementary to those of diffusivity
metrics. Kurtosis together with diffusivity can more
comprehensively characterize microstructural
compositions and age-related changes than diffusivity
alone. In terms of deep gray matter, higher MK and FA in
the globus pallidus, substantia nigra and red nucleus
mirrored the higher microstructural complexity and
directionality compared to putamen, caudate nucleus and
thalamus. In particular, we proposed that the unique
age-related increasing of FA, MK and KR in the putamen
may be resulted from iron deposition.
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