Meeting Banner
Abstract #4688

Age and Gender - Related Changes in the Normal Human Brain Using Hybrid Diffusion Imaging (HYDI) with Neurite Orientation Dispersion and Density Imaging (NODDI) Analysis

Chandana Kodiweera 1 , Andrew K Alexander 2 , and Yu-Chien Wu 1

1 Psychological and Brain Sciences, Dartmouth College, Hanover, New Hampshire, United States, 2 Department of Medical Physics, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, United States

To better characterize the findings of diffusion-weighted imaging with underlying biological and pathological changes of the human brain, several multiple-compartments diffusion models were proposed recently. In this study, we used Hybrid Diffusion Imaging (HYDI), a 5-shells diffusion-encoding scheme, with Neurite Orientation and Density Imaging (NODDI) data analysis. Fifty-two subjects aged from 18 to 72 years were studied. We found that the orientation dispersion index increases as age increases suggesting that the white matter organization loses coherence over age. While WM organization seems to be more sensitive with normal aging, the overall intracellular volume fraction remains stable over the aging course.

This abstract and the presentation materials are available to members only; a login is required.

Join Here