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Abstract #4692

Human post-mortem brain phantom as a standardization model for multicentre MRI studies

Amgad Droby 1 , Adriane Grger 1 , Isabella Spiwoks-Becker 2 , Anne Schnzer 3 , Till Acker 3 , Frauke Zipp 1 , and Ralf Deichmann 4

1 Neurology department-Neuroimaging center (NIC), Johannes Gutenberg university hospital, Mainz, Deutschland, Germany, 2 Institute of microanatomy and neurobiology, Johannes Gutenberg university hospital, Mainz, Deutschland, Germany, 3 Institute for neuropathology, Justus Liebig University, Giessen, Deutschland, Germany, 4 Brain Imaging Center (BIC), Goethe University, Frankfurt am Main, Deutschland, Germany

Multi-centre MRI studies are essential for enrolling large and diverse patient cohorts in the study of neurological diseases. Therefore, a multi-centre MRI standardization tool that mimics the in-vivo human brain is needed. Here, we provide evidence that a human post-mortem brain is a valid model for the standardization of multi-centre MRI studies. Using T1 mapping, T2, MTR and PD, the relaxation times of this model were found to be stable over the time course. Moreover, such a model can provide volumetric measures of GM and WM, which could also be used for intra- as well as inter-site comparisons.

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