Human post-mortem brain phantom as a standardization model for multicentre MRI studies
Amgad Droby 1 , Adriane Grger 1 , Isabella Spiwoks-Becker 2 , Anne Schnzer 3 , Till Acker 3 , Frauke Zipp 1 , and Ralf Deichmann 4
Neurology department-Neuroimaging center
(NIC), Johannes Gutenberg university hospital, Mainz,
of microanatomy and neurobiology, Johannes Gutenberg
university hospital, Mainz, Deutschland, Germany,
for neuropathology, Justus Liebig University, Giessen,
Imaging Center (BIC), Goethe University, Frankfurt am
Main, Deutschland, Germany
Multi-centre MRI studies are essential for enrolling
large and diverse patient cohorts in the study of
neurological diseases. Therefore, a multi-centre MRI
standardization tool that mimics the in-vivo human brain
is needed. Here, we provide evidence that a human
post-mortem brain is a valid model for the
standardization of multi-centre MRI studies. Using T1
mapping, T2, MTR and PD, the relaxation times of this
model were found to be stable over the time course.
Moreover, such a model can provide volumetric measures
of GM and WM, which could also be used for intra- as
well as inter-site comparisons.
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