Age-Dependent Changes in the Histograms of ADC Values

Readout-segmented EPI (rs-EPI) sequences were used in in clinical routine examinations. Calculated ADC histograms were were examined for the detection of of age-dependent brain volume losses. 783 patient measurements were performed with a 3T scanner. Data were checked visually and 233 data-sets with pathologies were excluded. The value of the relative number of pixels in the brain compartment of the histogram (ADC-values lower than 1.15 10 ^-3 mm ² /s) of each subject was evaluated. The results for all patients were drawn against age and fitted by a polynomial. The decrease of the fitted curve was stronger for men than for women.

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