Abstract #4702
Early detection of subtle neurodegeneration in non-cognitively impaired HIV patients using TBSS and VBM
Nicholas G Dowell 1 , Cynthia Wong 1 , Emilie Elliot 2 , Roshani Patel 2 , Paul S Tofts 1 , Martin Fisher 3 , and Mara Cercignani 1
1
Clinical Imaging Sciences Centre, Brighton
and Sussex Medical School, Falmer, Brighton and Hove,
United Kingdom,
2
Chelsea
and Westminster Hospital, London, United Kingdom,
3
Elton
John Centre, Brighton and Sussex University Hospital,
Brighton, United Kingdom
The introduction of highly-active antiretroviral therapy
(HAART) has increased the life expectancy and quality of
life of patients with human immunodeficiency virus
(HIV). In spite of this treatment, the incidence of
HIV-associated neurocognitive disorders has continued to
rise. Here we study 24 non-cognitively-implaired HIV+
patients (12 untreated, and 12 treated with HAART) to
detect early subtle brain changes. We use diffusion
tensor imaging and voxel-based morphometry to show that
mean diffusivity and radial diffusivity is significantly
increased in the patient cohort. Volume loss is also
detected among the patient group. This study reveals
that subtle brain changes can be detected before the
manifestation of cognitive deficit.
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