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Abstract #4716

31 P-MRSI at 7T in Parkinson's Disease

Silvina G. Horovitz 1 , Peter Lauro 1 , Andrew Van 1,2 , Pascal Sati 3 , Steve Li 4 , Pritha Ghosh 1 , Nora Vanegas-Arroyave 1 , Codrin I Lungu 5 , and Mark Hallett 1

1 Human Motor Control Section, NINDS - NIH, Bethesda, MD, United States, 2 Texas A&M University, Texas, United States, 3 Neuroinmunology Branch, NINDS - NIH, Bethesda, MD, United States, 4 MRS Core, NIMH, Bethesda, Maryland, United States, 5 NIH Parkinson Clinic, NINDS - NIH, Bethesda, MD, United States

Parkinson disease (PD) is a neurodegenerative disorder. Post-mortem studies suggest mitochondrial dysfunction in PD. We assessed mitochondrial function in vivo using phosphorus chemical shift imaging (31P-CSI) at 7T in a cohort of PD, Parkinsonian syndromes and healthy controls. Processing was performed using JMRIU, matlab and AFNI. Mitochondrial function was evaluated by phosphocreatine concentrations and compared to markers of membrane integrity in several brain areas affected by the disorder. High energy phosphates in most affected side of patients' substantia nigra showed significant decrease when compared to the less affected side and to healthy controls.

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