Abstract #4716
31 P-MRSI at 7T in Parkinson's Disease
Silvina G. Horovitz 1 , Peter Lauro 1 , Andrew Van 1,2 , Pascal Sati 3 , Steve Li 4 , Pritha Ghosh 1 , Nora Vanegas-Arroyave 1 , Codrin I Lungu 5 , and Mark Hallett 1
1
Human Motor Control Section, NINDS - NIH,
Bethesda, MD, United States,
2
Texas
A&M University, Texas, United States,
3
Neuroinmunology
Branch, NINDS - NIH, Bethesda, MD, United States,
4
MRS
Core, NIMH, Bethesda, Maryland, United States,
5
NIH
Parkinson Clinic, NINDS - NIH, Bethesda, MD, United
States
Parkinson disease (PD) is a neurodegenerative disorder.
Post-mortem studies suggest mitochondrial dysfunction in
PD. We assessed mitochondrial function in vivo using
phosphorus chemical shift imaging (31P-CSI) at 7T in a
cohort of PD, Parkinsonian syndromes and healthy
controls. Processing was performed using JMRIU, matlab
and AFNI. Mitochondrial function was evaluated by
phosphocreatine concentrations and compared to markers
of membrane integrity in several brain areas affected by
the disorder. High energy phosphates in most affected
side of patients' substantia nigra showed significant
decrease when compared to the less affected side and to
healthy controls.
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