Abstract #4719
Preliminary Diffusional Kurtosis Imaging of the substantia nigra in de novo Parkinson disease: Diagnostic Utility of Histogram Analysis
Koji Kamagata 1 , Masaaki Hori 1 , Kohei Kamiya 1 , Michimasa Suzuki 1 , Akira Nishikori 2 , Mariko Yoshida 1 , Fumitaka Kumagai 2 , Taku Hatano 3 , Hiroyuki Tomiyama 3 , Nobutaka Hattori 3 , and Shigeki Aoki 1
1
Department of Radiology, Juntendo University
School of Medicine, Tokyo, Bunkyo-ku, Japan,
2
Department
of Radiological Sciences, Tokyo Metropolitan University,
Tokyo, Japan,
3
Department
of Neurology, Juntendo University School of Medicine,
Tokyo, Bunkyo-ku, Japan
We preliminarily investigated the efficacy of analyzing
histograms of diffusional kurtosis imaging metrics to
diagnose Parkinson disease (PD) in vivo. The mean and
median values of FA and MK in the substantia nigra pars
compacta (SNpc) were significantly lower in PD patients
than in healthy controls (MannWhitney U test with
Bonferroni correction). The median MK in the SNpc showed
the best diagnostic performance (mean cutoff, 0.910;
sensitivity, 0.93; specificity, 0.83). Our results
demonstrate that histogram analysis of MK measurements
can be a useful tool to diagnose PD in vivo.
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