Abstract #4723
Longitudinal Changes in Glutamate in a Mouse Model of Tauopathy Measured by GluCEST
Rachelle Crescenzi 1,2 , Catherine DeBrosse 1,2 , Ravi Prakash Reddy Nanga 2 , Kevin D'Aquilla 2 , Hari Hariharan 2 , Ari Borthakur 2 , Virginia M.-Y. Lee 3 , and Ravinder Reddy 2
1
Biochemistry and Molecular Biophysics,
University of Pennsylvania, Philadelphia, PA, United
States,
2
Center
for Magnetic Resonance and Optical Imaging (CMROI),
University of Pennsylvania, Philadelphia, PA, United
States,
3
Center
for Neurodegenerative Disease Research (CNDR),
University of Pennsylvania, Philadelphia, PA, United
States
Glutamate is a wide-spread excitatory neurotransmitter,
and has been shown by magnetic resonance spectroscopy (MRS)
to decrease in the hippocampus of Alzheimers disease
patients. Here we have studied this quickly progressing
mouse model longitudinally, using GluCEST and 1H MRS to
measure the effects of progressive tau pathology on
glutamate levels. Glutamate increases during neuronal
development of adolescent mice, and decreases in the
thalamus/hypo-thalamus with the progression of tau
pathology. In two cases, extremely low GluCEST values
predicated early disease onset.
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