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Abstract #4726

Brain Perfusion and Glucose Metabolism by Simultaneous FDG-PET/MR-ASL in Patients with Cognitive Disorders: Initial Experience.

Marco Aiello 1 , Carlo Cavaliere 1 , Ilaria Boscolo Galeazzo 2 , Elena Salvatore 3 , Francesca B. Pizzini 4 , Alberto Beltramello 4 , and Emanuele Nicolai 1
1 IRCCS fondazione SDN, Naples, Italy, 2 University of Verona, Italy, 3 Universit di Napoli Federico II, Italy, 4 General Hospital, Verona, Italy

Simultaneous acquisition of brain metabolism and perfusion by hybrid FDG- PET/MR arterial spin labeling (ASL) may better characterise physio-pathological processes underpinning cognitive disorders. Many technical issues should be considered. While collecting patients group data, here we present 4 typical case-reports. We found a good agreement between blood perfusion and glucose metabolism in MCI and AD. As for as vascular dementia patient, a mismatch between perfusion and metabolism raised up, showing a decreased frontal perfusion in absence of significant metabolism reduction in these areas. These preliminary data show good feasibility in terms of image quality and patient endurance.

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