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Abstract #4729

Parietal white matter lesions increase the risk of conversion to AD in patients with amnestic MCI and higher levels cognitive reserve.

Laura Serra 1 , Massimo Musicco 2 , Mara Cercignani 3 , Mario Torso 1 , Barbara Span 1 , Roberta Perri 2 , Lucia Fadda 2 , Carlo Caltagirone 2 , and Marco Bozzali 1

1 Neuroimaging Laboratory, Santa Lucia Foundation, Rome, Italy, 2 Santa Lucia Foundation, Rome, Italy, 3 University of Sussex, Brighton, United Kingdom

Cognitive reserve (CR) in Alzheimer Disease (AD) accounts for differences among individuals in their ability to cope with cognitive decline. By using a questionnaire to assess CR and visual rating scales to assess gray matter atrophy and white matter abnormalities, we show an interaction between different levels of CR, severity of white matter lesions (but not severity of temporal lobe atrophy) with the relative risk of conversion to AD, in patients with amnestic Mild Cognitive Impairment. A specific interaction between CR, WM lesions and GM atrophy allows a quantification of the conversion time from a-MCI to AD.

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