Parietal white matter lesions increase the risk of conversion to AD in patients with amnestic MCI and higher levels cognitive reserve.
Laura Serra 1 , Massimo Musicco 2 , Mara Cercignani 3 , Mario Torso 1 , Barbara Span 1 , Roberta Perri 2 , Lucia Fadda 2 , Carlo Caltagirone 2 , and Marco Bozzali 1
Neuroimaging Laboratory, Santa Lucia
Foundation, Rome, Italy,
Lucia Foundation, Rome, Italy,
of Sussex, Brighton, United Kingdom
Cognitive reserve (CR) in Alzheimer Disease (AD)
accounts for differences among individuals in their
ability to cope with cognitive decline. By using a
questionnaire to assess CR and visual rating scales to
assess gray matter atrophy and white matter
abnormalities, we show an interaction between different
levels of CR, severity of white matter lesions (but not
severity of temporal lobe atrophy) with the relative
risk of conversion to AD, in patients with amnestic Mild
Cognitive Impairment. A specific interaction between CR,
WM lesions and GM atrophy allows a quantification of the
conversion time from a-MCI to AD.
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