Abstract #4736
Regional brain volume changes correlate with functional differences between APOE-e4+ and APOE-e4-
Nicholas G Dowell 1 , Simon L Evans 2 , Paul S Tofts 1 , Sarah L King 2 , Naji Tabet 3 , and Jennifer M Rusted 2
1
Clinical Imaging Sciences Centre, Brighton
and Sussex Medical School, Falmer, Brighton and Hove,
United Kingdom,
2
Psychology,
University of Sussex, Falmer, Brighton and Hove, United
Kingdom,
3
Postgraduate
Medicine, Brighton and Sussex Medical School, Falmer,
Brighton and Hove, United Kingdom
The presence of the APOE-e4 gene represents a
significantly higher risk factor for developing
Alzheimer's Disease. We scanned 80 healthy volunteers
across two age-groups(young group: 20 with the e4 gene
and 21 without, mid age group 17 with APOE-e4, 22
without). Our study identified local regional volume
change in brain areas that positively correlated with
fMRI activation between our two genetic groups. Brains
areas identified were parahippocampus, cuneus, occipital
and inferior parietal.
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