Meeting Banner
Abstract #4743

Assessment of cortical phase changes in Alzheimers disease patients at 3T using T2*-weighted imaging.

Sanneke van Rooden 1 , Naomi Smulders 1 , Maarten J. Versluis 1 , Annemarieke M. van Opstal 1 , Andrew G. Webb 1 , Mark A. van Buchem 1 , and Jeroen van der Grond 1

1 Radiology, Leiden University Medical Center, Leiden, Zuid-Holland, Netherlands

Recent findings suggested that the level of iron accumulation, which may reflect AD pathology and more specifically amyloid deposition, is reflected by phase information on T2*-weighted MRI at 7T. The aim of this study was to translate the imaging methods from 7T to 3T MRI to investigate whether these differences could be detected using T2*-weighted 3T MRI data. Our 3T MRI data show no phase differences between AD patients and controls as opposed to our previous 7T MRI data which showed an increased cortical phase shifts in AD patients, and an association with cognitive performance.

This abstract and the presentation materials are available to members only; a login is required.

Join Here