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Abstract #4746

Exploring amyloid-associated cerebral vasculopathy in an aged nonhuman primate model by multiparametric MRI

Silun Wang 1 , Jeromy Dooyema 2 , Xiaodong Zhang 1 , Lary C. Walker 2,3 , and Eric Heuer 2,4

1 Yerkes Imaging Center, Yerkes National Primate Research Center, Emory University, Atlanta, GA, United States, 2 Yerkes National Primate Research Center, Emory University, GA, United States, 3 Department of Neurology, Emory University, GA, United States, 4 University of Hawaii at Hilo, HI, United States

We analyzed the histopathologic correlates of age-associated vasculopathy in a unique nonhuman primate model of cerebral β-amyloid angiopathy using multiparametric MRI. Regions indicative of possible past microbleeds were detected as hypointense regions via SWI, and low ADC values were confirmed histologically to contain abundant hemosiderin, β-amyloid deposition, microgliosis and astrogliosis, but no demyelination. Our results support the use of SWI and DTI as potential imaging modalities to characterize cerebral vasculopathy and associated degenerative changes in the senescent brain.

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