Effects of pre-reperfusion NBO administration in experimental ischemic stroke

Normobaric hyperoxia (NBO) has shown to improve and worsen stroke outcomes in ischemic stroke. The positive outcome of NBO treatment in cerebral ischemia may depend on the treatment window and treatment duration which remain less explored. The goal of this study was to use quantitative MRI to longitudinally evaluate the effects of NBO in early pre-reperfusion treatment window (60 & 90 min reperfusion post MCAO) with varying NBO treatment duration (25 min & 50 min respectively). We conclude that NBO treatment along with reperfusion treatment reversed ADC lesion and salvaged tissue, and that longer treatment up to 50 min was more effective. We showed that NBO not only buy time and expand the treatment time window, but also that in pre reperfusion treatment window longer NBO treatment duration further salvages more tissues.

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