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Abstract #4787

Underlying mechanisms of Apparent Diffusion Coefficient changes in the stroke rat brain revealed via diffusion basis spectrum imaging and histological examinations

Yi-Hua Hsu 1 , Chien-Hsiang Huang 1 , Chiao-Chi V. Chen 1 , Yong Wang 2 , Peng Sun 2 , Sheng-Kwei Song 2 , and Chen Chang 1

1 Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Taiwan, 2 Department of Radiology, Washington University School of Medicine, St. Louis, MO, United States

Evaluating the brain with stroke is challenge because the progressive ischemic injury confounds MRI measurements. Diffusion weighted MRI has been shown to be sensitive in detecting acute ischemic lesions while losing its sensitivity and specificity to ischemic injury chronically. To demonstrate the underlying tissue changes leading to this loss of sensitivity and specificity of DWI, we employed in vivo diffusion basis spectrum imaging (DBSI), and post-imaging histology to assess the tissue structural changes in a stroke rat model. Results showed that DBSI specifically detects the ischemia-induced tissue damage and cell infiltration/proliferation.

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