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Abstract #4789

Altered sensorimotor network of resting state fMRI in Leukoaraiosis

Youzhi Lai 1 , Xia Wu 1,2 , and Li Yao 1,2

1 School of Information Science and Technology, Beijing Normal University, Beijing, Beijing, China, 2 State Key Laboratory of Cognitive Neuroscience and Learning, Beijing Normal University, Beijing, China

In this study, the sensorimotor network in resting state fMRI was investigated by group ICA and correlation analysis, for patients with leukoaraiosis (LA) and healthy controls. The results showed significant increased functional connectivity in medial volumes of dorsal posterior precuneus (DP-PCC), left lingual and supplementary motor area (SMA). Furthermore, the results also revealed a strong correlation between the visuospatial ability score of Montreal Cognitive Assessment (MoCA) and the number of positive z-scores in the DP-PCC. It was suggested that the motor dysfunction in patient with LA maybe associated with the impairment in visuospatial function.

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