Abstract #4874
Perfluorocarbon Lung Clearance Evaluated with Dual-Nuclei 19 F and 1 H MRI in the Context of Total Liquid Ventilation
Ludovic de Rochefort 1 , Mourad Chenoune 2 , Anis Ben Yahmed 1 , Charlotte Alibert 1 , Jrmy Ppin 1 , Fanny Lidouren 2 , Lys Darbera 2 , Alain Berdeaux 2 , Matthias Korn 1 , Rose-Marie Dubuisson 1 , Luc Darrasse 1 , Daniel Isabey 3 , and Renaud Tissier 2
1
IR4M, Univ. Paris-Sud, CNRS, UMR 8081, Orsay,
France,
2
Inserm
UMR 955-3, Univ Paris Est, Ecole Nationale Vtrinaire
de Maisons-Alfort, Maisons-Alfort, France,
3
Inserm
UMR 955-13, Univ Paris Est, Crteil, France
Fast hypothermia induced by Total Liquid Ventilation (TLV)
with Perfluorocarbons (PFC) has been shown to be
cardioprotective. TLV procedure includes a lung filling
phase, the ventilation, and a final clearance during
which PFCs are eliminated from the lungs. For the
potential clinical transfer, it is important to select
PFCs that are better tolerated, as the clearance phase
may vary with the PFC physical properties. Here, we
present the evaluation of the clearance from pig lungs
for three different liquid PFCs with a quantitative
dual-nuclei (1H, 19F) MRI protocol at 1.5 T providing
insights for selecting PFCs for human use
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