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Abstract #0024

In vivo measurement of vessel wall diffusion anisotropy in carotid arteries

Peter Opriessnig 1 , Harald Mangge 1 , Rudolf Stollberger 2 , David Porter 3 , Hannes Deutschmann 4 , and Gernot Reishofer 5

1 Clinical Institute for Medical and Chemical Laboratory Diagnosis, Medical University of Graz, Graz, Austria, 2 Institute of Medical Engineering, Graz University of Technology, Austria, 3 MR R&D, Siemens AG, Healthcare Sector, Erlangen, Germany, 4 Department of Radiology, Division of Vascular and Interventional Radiology, Medical University of Graz, Austria, 5 Department of Radiology, Division of Neuroradiology, Medical University of Graz, Austria

Multi-contrast MRI has become a well-recognized tool to study the complexity of an atherosclerotic plaque in order to predict lesion vulnerability. Diffusion tensor imaging (DTI) could be an additional measure that provides information on the influence of plaque components on the diffusion process, which may help to understand the formation of a complex disease. In this work, we demonstrate the feasibility to investigate the orientation of diffusion anisotropy in healthy human carotids in vivo. Tangential and radial diffusion were measured by the combination of a read-out segmented EPI (rs-EPI) with a 2D special gradient direction scheme.

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