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Abstract #0029

Selective magnetic resonance imaging of magnetic nanoparticles by Acoustically Induced Rotary Saturation (AIRS)

Bo Zhu 1,2 , Thomas Witzel 1 , Shan Jiang 3 , Susie Y. Huang 1 , Bruce R. Rosen 1,4 , and Lawrence L. Wald 1,2

1 Martinos Center for Biomedical Imaging, Department of Radiology, Massachusetts General Hospital, Charlestown, MA, United States, 2 Harvard-MIT Division of Health Sciences Technology, Massachusetts Institute of Technology, Cambridge, MA, United States, 3 David H Koch Institute for Integrative Cancer Research, Department of Chemical Engineering, Massachusetts Institute of Technology, Cambridge, MA, United States, 4 Department of Meridian & Acupuncture, Collaborating Center for Traditional Medicine, East-West Medi, Kyung Hee University, Seoul, Korea

The manual image interpretation process typically required to locate magnetic nanoparticle contrast agents from pre- and post-injection scans often results in ambiguous identifications. We present a resonant spin-lock acquisition technique to selectively image iron oxide contrast agents within an entirely post-injection paradigm, offering more certain localization of iron oxide presence for research and clinical studies. The ability to perform block-design experiments with the methods rapidly modulatable agent contrast further enables quantitative statistical analysis, extending the robustness and flexibility of iron oxide nanoparticles as an investigative molecular imaging tool.

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