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Abstract #0034

Automatic and Quantitative Assessment of Total and Regional Muscle Tissue Volume using Multi-Atlas Segmentation

Anette Karlsson 1,2 , Johannes Rosander 3 , Joakim Tallberg 2 , Anders Grnqvist 2,4 , Magnus Borga 1,2 , and Olof Dahlqvist Leinhard 2,5

1 Department of Biomedical Engineering (IMT), Linkping University, Linkping, Sweden, Sweden, 2 Center for Medical Image Science and Visualization (CMIV), Linkping University, Linkping, Sweden, 3 Advanced MR Analytics (AMRA) AB, Linkping, Sweden, 4 Department of Radiation Physics and Department of Medical and Health Sciences, Linkping University, Linkping, Sweden, 5 Department of Medical and Health Sciences (IMH), Linkping University, Linkping, Sweden

The purpose is to develop and demonstrate a rapid whole-body MRI method for automatic quantification of total and regional lean skeletal muscle volume. Quantitative water and fat separated image volumes of the whole body are manually segmented and used as atlases. The atlases are non-rigidly registered onto to a new image volume and the muscle groups are classified using a voting scheme. A leave-one-out approach with subjects scanned in a 1.5 T and a 3.0 T scanner is used for validation. The method quantifies the whole-body skeletal muscle volumes and the volumes of separate muscle groups independently of image resolution.

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