Abstract #0036
Multi-parametric MRI Assessment of Tumor Response to High-Intensity Focused Ultrasound in a Rat Glioma Model
Yi Zhang 1 , Dong-Hoon Lee 1 , Kai Zhang 1 , Antonella Mangraviti 2 , Chen Yang 1 , Hye-Young Heo 1 , Betty Tyler 2 , Ari Partanen 3 , Keyvan Farahani 1,4 , Paul Bottomley 1 , Peter van Zijl 1,5 , and Jinyuan Zhou 1,5
1
Division of MR Research, Department of
Radiolgoy, Johns Hopkins University, Baltimore,
Maryland, United States,
2
Department
of Neurosurgery, Johns Hopkins University, Baltimore,
Maryland, United States,
3
Clinical
Science MR Therapy, Philips Healthcare, Andover,
Massachusetts, United States,
4
National Cancer
Institue, Bethesda, Maryland, United States,
5
F.
M. Kirby Research Center for Functional Brain Imaging,
Kennedy Krieger Institute, Baltimore, Maryland, United
States
MRI-guided HIFU is a promising non-invasive therapy for
treating tumors. Amide proton transfer-weighted (APTw)
imaging is an emerging MRI technique that is sensitive
to changes in tissue protein and peptide levels and
molecular exchange properties. Here, APTw imaging is
used to assess the effects of HIFU treatment effects in
a longitudinal rat brain tumor model up to 6 days
post-treatment. APTw measurements are compared with
conventional MRI indicesrelaxation times, diffusion,
perfusion and the magnetization transfer ratio. The
results suggest that APTwMRI may detect treatment
changes earlier than other MRI metrics.
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