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Abstract #0036

Multi-parametric MRI Assessment of Tumor Response to High-Intensity Focused Ultrasound in a Rat Glioma Model

Yi Zhang 1 , Dong-Hoon Lee 1 , Kai Zhang 1 , Antonella Mangraviti 2 , Chen Yang 1 , Hye-Young Heo 1 , Betty Tyler 2 , Ari Partanen 3 , Keyvan Farahani 1,4 , Paul Bottomley 1 , Peter van Zijl 1,5 , and Jinyuan Zhou 1,5

1 Division of MR Research, Department of Radiolgoy, Johns Hopkins University, Baltimore, Maryland, United States, 2 Department of Neurosurgery, Johns Hopkins University, Baltimore, Maryland, United States, 3 Clinical Science MR Therapy, Philips Healthcare, Andover, Massachusetts, United States, 4 National Cancer Institue, Bethesda, Maryland, United States, 5 F. M. Kirby Research Center for Functional Brain Imaging, Kennedy Krieger Institute, Baltimore, Maryland, United States

MRI-guided HIFU is a promising non-invasive therapy for treating tumors. Amide proton transfer-weighted (APTw) imaging is an emerging MRI technique that is sensitive to changes in tissue protein and peptide levels and molecular exchange properties. Here, APTw imaging is used to assess the effects of HIFU treatment effects in a longitudinal rat brain tumor model up to 6 days post-treatment. APTw measurements are compared with conventional MRI indicesrelaxation times, diffusion, perfusion and the magnetization transfer ratio. The results suggest that APTwMRI may detect treatment changes earlier than other MRI metrics.

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