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Abstract #0039

White-Matter-Nulled MP-RAGE Permits Patient-Specific Tracking of Focused Ultrasound Thalamic Ablation for Essential Tremor

Jason Su 1 , Thomas Tourdias 2 , Manojkumar Saranathan 3 , Casey Halpern 4 , Kim Butts-Pauly 3 , Jaimie Henderson 4 , Pejman Ghanouni 3 , and Brian K. Rutt 3

1 Electrical Engineering, Stanford University, Stanford, California, United States, 2 Neuroradiology, Bordeaux University Hospital, Bordeaux, France, 3 Neuroradiology, Stanford University, Stanford, California, United States, 4 Neurosurgery, Stanford University, Stanford, California, United States

The treatment of 7 essential tremor patients with MR guided focused ultrasound (MRgFUS) ablation of the ventral intermediate nucleus (Vim) in the thalamus was visualized with the white matter nulled MP-RAGE contrast (WMnMPRAGE). Manual segmentation of thalamic nuclei was performed on 7T scans, then registered to post-treatment 3T images. Overlays were produced showing the ablation zone and its position within the nucleus of interest. The ablation zone was revealed to be consistently between the center and inferior edge of Vim, within 1-2mm of the inferior edge. The consistent location demonstrated the functional validity of our thalamic imaging and segmentation methodology.

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