White-Matter-Nulled MP-RAGE Permits Patient-Specific Tracking of Focused Ultrasound Thalamic Ablation for Essential Tremor
Jason Su 1 , Thomas Tourdias 2 , Manojkumar Saranathan 3 , Casey Halpern 4 , Kim Butts-Pauly 3 , Jaimie Henderson 4 , Pejman Ghanouni 3 , and Brian K. Rutt 3
Electrical Engineering, Stanford University,
Stanford, California, United States,
Bordeaux University Hospital, Bordeaux, France,
Stanford University, Stanford, California, United
Stanford University, Stanford, California, United States
The treatment of 7 essential tremor patients with MR
guided focused ultrasound (MRgFUS) ablation of the
ventral intermediate nucleus (Vim) in the thalamus was
visualized with the white matter nulled MP-RAGE contrast
(WMnMPRAGE). Manual segmentation of thalamic nuclei was
performed on 7T scans, then registered to post-treatment
3T images. Overlays were produced showing the ablation
zone and its position within the nucleus of interest.
The ablation zone was revealed to be consistently
between the center and inferior edge of Vim, within
1-2mm of the inferior edge. The consistent location
demonstrated the functional validity of our thalamic
imaging and segmentation methodology.
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