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Abstract #0041

Hybrid MR/US-guided HIFU for abdominal targets: in vivo demonstration of 3D motion correction and focal point locking on an absolute reference marker

Lorena Petrusca 1 , Gibran Manasseh 2 , Zarko Celicanin 3 , Romain Breguet 4 , Oliver Bieri 3 , Vincent Auboiroux 5 , Christoph D Becker 4 , Sylvain Terraz 4 , and Rares V. Salomir 6

1 University of Geneva, Geneva, Geneva, Switzerland, 2 Radiology, University Hospitals of Geneva, Geneva, Switzerland, 3 University Hospital Basel, Basel, Switzerland, 4 University Hospitals of Geneva, Geneva, Switzerland, 5 LETI CEA, Grenoble, France, France, 6 Radiology, University Hospitals of Geneva, Geneva, Geneva, Switzerland

Treatments using high-intensity focused ultrasound (HIFU) in the abdominal region remain challenging due to respiratory organ motion. Various methods have been attempted in the past to achieve motion-compensated HIFU therapy, using ultrasound (US) imaging, magnetic resonance imaging (MRI), or both simultaneously. Here, a truly hybrid US-MRI guided HIFU (US-MRgHIFU) method was used to plan and control the treatment in vivo. 3D prospective motion correction was implemented at a frame rate of 15Hz on pig liver and kidney. An absolute target was used to demonstrate the spatial accuracy of the method, which was found to be in the sub-millimeter range.

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