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Abstract #0053

Anisotropy of local functional connectivity (LFC) in resting state fMRI time series: what does it say about the fmri signal?

Michael J. Tobia 1 , David Gallagher 1 , Rahul Dewal 1 , Prasanna Karunanayaka 1 , Sebastien Rupprecht 1 , and Qing X. Yang 1

1 Center for NMR Research, Penn State University, Hershey, PA, United States

This experiment investigated anisotropic local functional connectivity (LFC) in GE-EPI time series in phantom and human in vivo resting state fMRI data. LFC was computed in a neighborhood radius of 2 voxels using Pearsons correlation. In vivo, LFC anisotropy varied across gray and white matter sites, resembling DTI in some aspects, while differing on others. Phantom experiments showed that fluctuating electric current is sufficient to generate anisotropic LFC proximal to the current-carrying filament. In conclusion, anisotropic correlations of fMRI time series may arise from an alternative non-BOLD contrast mechanism, potentially related to an electric current effect on Bo.

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