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Abstract #0085

Systematic comparison between modified Dixon MRI techniques, MR spectroscopic relaxometry, and different histologic quantification methods in the assessment of fatty liver disease

Guido Matthias Kukuk 1 , Alois Martin Sprinkart 1 , Wolfgang Block 1 , Holger Eggers 2 , Jrgen Gieseke 1,3 , Kanishka Hittatiya 1 , Patrick Kupczyk 1 , Julian Luetkens 1 , Rami Homsi 1 , Vera Keil 1 , Michael Meier-Schroers 1 , Milka Marinova 1 , Asadeh Lakghomi 1 , Dariusch Hadizadeh 1 , Hans Heinz Schild 1 , and Frank Trber 1

1 University of Bonn, Bonn, NRW, Germany, 2 Philips Research Europe, Hamburg, Hamburg, Germany, 3 Philips Healthcare, Best, NL, Netherlands

The availability of various non-invasive and invasive techniques for liver fat quantification raises the question for comparability and congruence of quantitative results. Therefore we performed a systematic comparison of mDixon MRI techniques, MRS and two different histologic methods for liver fat quantification. Our results demonstrate that six-echo-mDixon, MRS and semi-automatic histologic fat quantification provide the most robust and congruent data. The performance characteristics and systematic differences of the various fat quantification methods should be considered in clinical routine and in further studies when comparing results obtained from biopsy with quantitative MRI or MRS.

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