Abstract #0087
Quantitative Ultra-short Echo Time Imaging for Massive Iron Overload Assessment: A Way to Make It Happen
Axel J. Krafft 1,2 , Ralf B. Loeffler 1 , Ruitian Song 1 , Mary E. McCarville 1 , Matthew D. Robson 3 , Jane S. Hankins 4 , and Claudia M. Hillenbrand 1
1
Radiological Sciences, St. Jude Children's
Research Hospital, Memphis, TN, United States,
2
Radiology
- Medical Physics, University Medical Center Freiburg,
German Cancer Consortium (DKTK), Heidelberg, Germany,
3
Radcliffe
Department of Medicine, University of Oxford, Oxford,
United Kingdom,
4
Hematology, St. Jude
Children's Research Hospital, Memphis, TN, United States
Iron overload requires accurate assessment of hepatic
iron content (HIC) which can be achieved via R2*-MRI
using multi-echo gradient echo (mGRE) imaging. The
precision in previous R2*-HIC studies is compromised for
high HIC (> 20 mg Fe/g) as conventional mGRE techniques
fail due to the rapid T2* signal decay. This limitation
could be overcome using 2D ultra-short echo time (UTE)
imaging which is, however, sensitive to various system
imperfections hampering quantitative MRI. We describe a
2D UTE sequence that allows for precise R2*
quantification for detection of iron overload. The
sequence was evaluated in phantoms and in vivo.
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