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Abstract #0095

Hyperpolarized Metabolic MR Imaging of Acute Myocardial Changes and Recovery Upon Ischemia-Reperfusion

Patrick Wespi 1 , Darach O h-Ici 1,2 , Julia Busch 1 , Lukas Wissmann 1 , Marcin Krajewski 1 , Kilian Weiss 1 , Andreas Sigfridsson 1 , Daniel Messroghli 2 , and Sebastian Kozerke 1,3

1 Institute for Biomedical Engineering, University and ETH Zurich, Zurich, Switzerland, 2 Department of Congenital Heart Disease and Pediatric Cardiology, German Heart Institute, Berlin, Germany, 3 Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom

The aim of the present work was to study in vivo the metabolic changes following left coronary artery occlusion. Rats were scanned using hyperpolarized [1-13C] pyruvate before coronary occlusion and directly after reopening of the coronary artery after 15 minutes of ischemia. Scans were repeated throughout the first hour of reperfusion, and then at 1 week following coronary occlusion. Data were correlated to local regional function using cine imaging and to myocardial injury based on late gadolinium enhancement (LGE) imaging. Myocardial metabolism was abnormal in the area-at-risk during the first 60 minutes following ischemia, but returned to normal one week later.

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