Meeting Banner
Abstract #0102

Off-resonance positive contrast flow imaging using extraneous paramagnetic biomarker-induced spin labeling

Jessica A.M. Bastiaansen 1,2 , Helene Feliciano 1,2 , Andrew Coristine 1,2 , and Matthias Stuber 1,2

1 Department of Radiology, University Hospital (CHUV) and University of Lausanne (UNIL), Lausanne, Switzerland, 2 Center for Biomedical Imaging (CIBM), Lausanne, Switzerland

By exploiting the frequency dispersion of protons residing in the dipolar field of FeO constrast agents that are injected intravenously, positive contrast MRI is enabled. Here, off-resonance imaging was exploited to explore positive contrast generation by using extraneous paramagnetic biomarkers, specifically targeting the labeling of moving protons. Spin labeling was thus achieved in a flow phantom using off-resonant imaging. Different delay times of the saturation pulse lead to a more extensive range of labeled spins, and time resolved positive contrast imaging of downstream areas. It allows for flow visualization in the vicinity of paramagnetic objects without the need for contrast injection.

This abstract and the presentation materials are available to members only; a login is required.

Join Here