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Abstract #0108

In Vivo Simultaneous Acquisition of Diffusion Tensor Imaging (DTI) and MR Elastography (MRE) in Mouse Brain

Ziying Yin 1 , Steven Kearney 2 , Richard L. Magin 1 , and Dieter Klatt 1

1 1Richard and Loan Hill Department of Bioengineering, University of Illinois at Chicago, Chicago, IL, United States, 2 2Department of Mechanical and Industrial Engineering, University of Illinois at Chicago, Chicago, IL, United States

Here we introduce a recipe for the simultaneous acquisition of Diffusion tensor imaging (DTI) and 3D-vector field MR Elastography (MRE) data. The simultaneous encoding of MRE and diffusion is first achieved by modulating the timing of the motion-sensitizing gradient with the diffusion time, and with the mechanical vibration frequency. The simultaneous acquisition of a 3D-vector field MRE and DTI is then achieved by designing a particular gradient encoding scheme with the application of a series of motion-sensitizing gradients in non-collinear and non-coplanar directions. The present work demonstrates the feasibility of the proposed concept in the mouse brain in vivo.

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