Abstract #0141
Correlating post-operative whole mount immunohistochemistry to functional MRI parameters in pancreatic cancer
Remy Klaassen 1,2 , Anne Steins 1,2 , Oliver J. Gurney-Champion 3 , Maarten F. Bijlsma 2 , Hessel Wijkstra 4 , Geertjan van Tienhoven 5 , Marc G.H. Besselink 6 , Johanna W. Wilmink 1 , Mark J. van de Vijver 7 , Jaap Stoker 3 , Aart J. Nederveen 3 , and Hanneke W.M. van Laarhoven 1
1
Department of Medical Oncology, Academic
Medical Center, Amsterdam, Netherlands,
2
Laboratory
for Experimental Oncology and Radiobiology, Academic
Medical Center, Amsterdam, Netherlands,
3
Department
of Radiology, Academic Medical Center, Amsterdam,
Netherlands,
4
Department
of Urology, Academic Medical Center, Amsterdam,
Netherlands,
5
Department
of Radiation Oncology, Academic Medical Center,
Amsterdam, Netherlands,
6
Department of
Surgery, Academic Medical Center, Amsterdam,
Netherlands,
7
Department
of Pathology, Academic Medical Center, Amsterdam,
Netherlands
Magnetic Resonance Imaging (MRI) enables the
non-invasive characterization of the pancreas tumor
microenvironment. Using diffusion weighted imaging,
water diffusivity can be used as measure for stromal
deposition and dynamic contrast enhanced MRI provides
further insight on tumor vascularization. Although these
sequences provide valuable information on macro scale,
interpretation of the underlying biological processes is
not unambiguous. In this pilot study we show the
feasibility of matching post-operative axial tissue
slices to in vivo MRI of the pancreas. Matching
immunohistochemically stained whole mount tissue slices
provides direct information on localization and local
tumor heterogeneity for biological correlation of
functional MRI parameters.
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