Abstract #0151
Validation of orientation distribution functions in 3D using confocal microscopy
Kurt Schilling 1 , Yurui Gao 1 , Vaibhav Janve 1 , Iwona Stepniewska 2 , Prasanna Parvathaneni 3 , Hua Li 1 , Bennett A Landman 4 , and Adam W Anderson 1
1
VUIIS, Vanderbilt University, Nashville, TN,
United States,
2
Psychology,
Vanderbilt University, Nasvhille, United States,
3
Electrical
Engineering, Vanderbilt University, TN, United States,
4
Electrical
Engineering, Vanderbilt University, Nashville, TN,
United States
Validation of fiber orientation and anisotropy estimates
from diffusion MRI (dMRI) studies has so far been
limited to 2D analysis of histological sections. Here,
we use structure tensor analysis to extract the 3D
histological fiber orientation distribution (FOD) from
confocal z-stacks, which then serves as a gold standard
for comparisons with various dMRI acquisition protocols
and signal models. Our results show good agreement
between histological and dMRI estimates of fiber
orientation in voxels containing nearly parallel fibers.
Further, we find that Q-ball and DSI analysis are also
able to resolve crossing fibers with similar accuracy.
How to access this content:
For one year after publication, abstracts and videos are only open to registrants of this annual meeting. Registrants should use their existing login information. Non-registrant access can be purchased via the ISMRM E-Library.
After one year, current ISMRM & ISMRT members get free access to both the abstracts and videos. Non-members and non-registrants must purchase access via the ISMRM E-Library.
After two years, the meeting proceedings (abstracts) are opened to the public and require no login information. Videos remain behind password for access by members, registrants and E-Library customers.
Click here for more information on becoming a member.
