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Abstract #0170

Longitudinal characterization of brain microstructure and visuomotor behavior following acute ocular hypertension using diffusion tensor imaging, magnetization transfer imaging and optokinetics

Yolandi van der Merwe 1,2 , Leon C. Ho 1,3 , Xiaoling Yang 1,4 , Michael B. Steketee 4 , Seong-Gi Kim 1,5 , Gadi Wollstein 4 , Joel S. Schuman 2,4 , and Kevin C. Chan 1,4

1 Neuroimaging Laboratory, University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 2 Department of Bioengineering, Swanson School of Engineering, University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 3 Department of Electrical and Electronic Engineering, University of Hong Kong, Pokfulam, Hong Kong, China, 4 Department of Ophthalmology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States, 5 Center for Neuroscience Imaging Research, Institute for Basic Science, Sungkyunkwan University, Suwon, Korea

An increase in intraocular pressure (IOP) is often associated with vision-related diseases like glaucoma and retinal ischemia, and cardiovascular diseases such as stroke. There exists a need to understand what happens in the visual pathway regarding function, structural integrity, and metabolic activity as these diseases progress. Here we used a model of ocular hypertension (OHT) induction to mimic the effects on the visual system observed in IOP increased neurodegenerative diseases. Diffusion tensor imaging, magnetization transfer imaging, and optokinetics were employed to longitudinally analyze the microstructural integrity and visuomotor behavior following OHT to help understand the disease mechanisms associated with elevated IOP.

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