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Abstract #0181

Dual Agent Relaxivity Cancellation (DARC) Imaging, a Novel Imaging Method for Dark Blood Post-Contrast Imaging: Application to MR Lymphangiography

Jeffrey H Maki 1 , Noah Briller 1 , Peter C Neligan 2 , and Gregory J Wilson 1

1 Radiology, University of Washington, Seattle, WA, United States, 2 Plastic Surgery, University of Washington, Seattle, WA, United States

A novel MR imaging method using two contrast agents (one for enhancement of non-blood-pool tissues, and one for suppression of blood-pool signal), named Dual Agent Relaxivity Cancellation (DARC), was developed for the visualization of lymphatic channels. The MR lymphangiography technique utilizes the T1 signal enhancement of intracutaneously injected gadobenate and the blood-pool T2* signal suppression of intravenously injected ferumoxytol. When imaged with mDixon using relatively long TEs (4-8ms), lymphatic channels are easily visualized without venous overlay.

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