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Abstract #0291

Estimation of a PET AIF using DSC MRI

John Lee 1 , Colin Derdeyn 1 , and Joshua Shimony 1

1 Washington University School of Medicine, Saint Louis, MO, United States

Bayesian modeling and parameter estimation predict arterial input functions for H 2 [ 15 O] PET using information from whole-brain PET tracer inflows and DSC MRI. Validation of normalized arterial input functions was achieved in 18 patients with clinically significant cerebrovascular disease. The approach may be a useful adjunct to perfusion studies on the new generation of PET/MRI scanners.

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