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Abstract #0295

Cerebral venous thrombosis: direct thrombus imaging with sub-millimeter isotropic resolution dark-blood MRI

Zhaoyang Fan 1 , Qi Yang 1,2 , Xiaofeng Qu 1,3 , Yibin Xie 1,4 , Guoxi Xie 5 , Tianyi Qian 6 , Xiaoming Bi 7 , Yutaka Natsuaki 7 , and Debiao Li 1

1 Biomedical Imaging Research Institute, Cedars-Sinai Medical Center, Los Angeles, California, United States, 2 Radiology, Xuanwu Hospital, Beijing, China, 3 Radiology, The Second Hospital OF Dalian Medical University, Dalian, China, 4 Bioengineering, University of California, Los Angeles, California, United States, 5 Shenzhen Institutes of Advanced Technology, Chinese Academy of Sciences, Guangdong, China, 6 MR Collaboration NE Asia, Siemens Healthcare, Beijing, China, 7 MR R&D, Siemens Healthcare, Los Angeles, California, United States

Cerebral venous thrombosis (CVT) is a disorder potentially leading to devastating disability and even death if not timely diagnosed and treated. Diagnosis is challenging with the current clinical imaging modalities due to various image artifacts and the variation in venous anatomy. We hypothesized that high-spatial-resolution dark-blood MRI, commonly used for artery wall imaging, may be a useful tool. In this work, a T1-weighted DANTE-prepared 3D TSE technique was developed to provide direct visualization of thrombus and surrounding anatomic structures in cerebral venous system. Our preliminary clinical study demonstrated that the technique may outweigh TOF MRV in diagnosing CVT.

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