Abstract #0300
Analysis of DNA Double-Strand Breaks in human Peripheral Blood Mononuclear Cells after exposure to 7T MRI
Mahsa Fatahi 1 , Annika Reddig 2 , Bjoern Friebe 3 , Dirk Reinhold 2 , and Oliver Speck 1
1
Department of Biomedical Magnetic Resonance,
Otto-von-Guericke-University Magdeburg, Magdeburg,
Germany,
2
Institute
of Molecular and Clinical Immunology,
Otto-von-Guericke-University Magdeburg, Germany,
3
Department
of Radiology and Nuclear Medicine,
Otto-von-Guericke-University Magdeburg, Germany
Although ultra-high field magnetic resonance imaging
(UHF MR) has been applied for 10 years with a very good
safety record, the scientific basis for safe use in
broader clinical applications is weak. In this in vitro
study, we addressed the question of the potential
genetic damage, particularly induction of DNA
double-strand breaks. We assessed the impact of 7T MRI
scans on induction of DSBs on human Peripheral blood
mononuclear cells (PBMC). Our results showed no
significant increase in DSBs level, in all individuals,
immediately, 1 h and 20 h after 7T MRI exposure,
compared to the unexposed group.
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