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Abstract #0300

Analysis of DNA Double-Strand Breaks in human Peripheral Blood Mononuclear Cells after exposure to 7T MRI

Mahsa Fatahi 1 , Annika Reddig 2 , Bjoern Friebe 3 , Dirk Reinhold 2 , and Oliver Speck 1

1 Department of Biomedical Magnetic Resonance, Otto-von-Guericke-University Magdeburg, Magdeburg, Germany, 2 Institute of Molecular and Clinical Immunology, Otto-von-Guericke-University Magdeburg, Germany, 3 Department of Radiology and Nuclear Medicine, Otto-von-Guericke-University Magdeburg, Germany

Although ultra-high field magnetic resonance imaging (UHF MR) has been applied for 10 years with a very good safety record, the scientific basis for safe use in broader clinical applications is weak. In this in vitro study, we addressed the question of the potential genetic damage, particularly induction of DNA double-strand breaks. We assessed the impact of 7T MRI scans on induction of DSBs on human Peripheral blood mononuclear cells (PBMC). Our results showed no significant increase in DSBs level, in all individuals, immediately, 1 h and 20 h after 7T MRI exposure, compared to the unexposed group.

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