Navigated PSF Mapping for Distortion-Free High-Resolution In-Vivo Diffusion Imaging at 7T

For high-resolution diffusion-weighted imaging, which is used for microstructural characterization of human brain in research as well as clinical applications, single-shot echo-planar imaging may be not suitable due to severe T2 blurring and susceptibility- and eddy-current-induced geometric distortions, especially at ultra-high field. Several multi-shot approaches have been proposed to mitigate such effects. In this study, a point-spread function based diffusion-weighted imaging approach is newly proposed. In contrast to multi-shot approaches, this method doesnt suffer any T2 blurring and geometric distortions and enables a clear and detailed delineation of human brain structures in-vivo.

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