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Abstract #0351

A generative model of white matter axonal orientations near the cortex

Michiel Cottaar 1 , Saad Jbabdi 1 , Matthew F Glasser 2 , Krikor Dikranian 2 , David C van Essen 2 , Timothy E Behrens 1 , and Stamatios N Sotiropoulos 1

1 FMRIB Centre, University of Oxford, Oxford, United Kingdom, 2 Washington University School of Medicine, Saint Louis, Missouri, United States

Close to the cortical surface axons often bend towards the surface on a spatial scale unresolved in diffusion MRI, which causes these bends to be missed by classical tractography algorithms. Here we present a simple model, which with a single free parameter can reproduce the fibre orientation measured in a high-resolution myelin-stained macaque gyral slice within 4 degrees. This low-parameter model can be fitted to the dispersion orbital distribution function measured in diffusion MRI to reproduce the sub-voxel fibre bending to the cortical surface and hence the cortical connectivity.

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