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Abstract #0361

Single Venule Multi-Echo Line-Scanning fMRI (MELS-fMRI)

Yi He 1,2 , Hellmut Merkle 3 , and Xin Yu 1,2

1 Research Group of Translational Neuroimaging and Neural Control, High-Field Magnetic Resonance, Max Planck Institute for Biological Cybernetics, Tuebingen, Baden-Wuerttemberg, Germany, 2 Graduate School of Neural Information Processing, University of Tuebingen, Tuebingen, Baden-Wuerttemberg, Germany, 3 Laboratory of Functional and Molecular Imaging, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, United States

In contrast to the traditional T2*-weighted EPI-fMRI signal, the T2* fMRI signal is more specific with less temporal noise interference. We developed a multi-Echo Line-Scanning fMRI (MELS-fMRI) method to map T2* signal in a block design stimulation paradigm with 100ms sampling rate. Individual penetrating venules can be directly identified from the raw image with 100x100m spatial resolution. The spatial pattern of single-venule fMRI signal was detected from 3 ms to 20.5 ms with 3.5ms interval. It is the first step to decipher the millisecond scale fMRI signal propagation across cerebrovasculature in the deep layer cortex.

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