Abstract #0361
Single Venule Multi-Echo Line-Scanning fMRI (MELS-fMRI)
Yi He 1,2 , Hellmut Merkle 3 , and Xin Yu 1,2
1
Research Group of Translational Neuroimaging
and Neural Control, High-Field Magnetic Resonance, Max
Planck Institute for Biological Cybernetics, Tuebingen,
Baden-Wuerttemberg, Germany,
2
Graduate
School of Neural Information Processing, University of
Tuebingen, Tuebingen, Baden-Wuerttemberg, Germany,
3
Laboratory
of Functional and Molecular Imaging, National Institute
of Neurological Disorders and Stroke, National
Institutes of Health, Bethesda, MD, United States
In contrast to the traditional T2*-weighted EPI-fMRI
signal, the T2* fMRI signal is more specific with less
temporal noise interference. We developed a multi-Echo
Line-Scanning fMRI (MELS-fMRI) method to map T2* signal
in a block design stimulation paradigm with 100ms
sampling rate. Individual penetrating venules can be
directly identified from the raw image with 100x100m
spatial resolution. The spatial pattern of single-venule
fMRI signal was detected from 3 ms to 20.5 ms with 3.5ms
interval. It is the first step to decipher the
millisecond scale fMRI signal propagation across
cerebrovasculature in the deep layer cortex.
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