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Abstract #0403

Free water elimination DTI in preclinical Alzheimer's: evidence for early axonal degeneration

Andrew R. Hoy 1,2 , Sterling C. Johnson 3,4 , Ozioma C. Okonkwo 4,5 , Cynthia M. Carlsson 3,4 , Henrik Zetterberg 6 , Kaj Blennow 7 , Sanjay Asthana 3,4 , Mark A. Sager 4,5 , Andrew L. Alexander 1,8 , and Barbara B. Bendlin 4,5

1 Medical Physics, University of Wisconsin, Madison, Wisconsin, United States, 2 Medical Service Corp, United States Navy, Falls Church, Virginia, United States, 3 Geriatric Research, Education and Clinical Center, William S. Middleton Memorial Veteran's Hospital, Madison, Wisconsin, United States, 4 Wisconsin Alzheimer's Disease Research Center, University of Wisconsin, Madison, Wisconsin, United States, 5 Wisconsin Alzheimer's Institute, University of Wisconsin, Madison, Wisconsin, United States, 6 Institute of Neuroscience and Physiology, Department of Psychiatry and Neurochemistry, University of Gothenberg, Gothenberg, Sweden, 7 Department of Clinical Neuroscience, University of Gothenberg, Gothenberg, Sweden, 8 Waisman Laboratory for Brain Imaging and Behavior, University of Wisconsin, Madison, Wisconsin, United States

This study is the first to investigate the association between CSF markers and white matter microstructure in an asymptomatic population using the FWE-DTI model. A targeted tractography method and voxel based analysis was used to demonstrate a relation between pTau181 and NFL and the FWE isotropic volume fraction. Given that tau and NFL are components of the axonal cytoskeleton our results suggest that f-value may be sensitive to early axonal degeneration. Our results suggest that diffusion imaging with FWE may hold promise for early disease detection, in addition to providing a novel outcome measure for prevention and treatment trials.

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