Concurrent Optical and Magnetic Resonance Microscopy
Frederik Testud 1 , Elmar Fischer 1 , Katharina Gbel 1 , Nils Spengler 2 , Ulrike Wallrabe 2 , Maxim Zaitsev 1 , and Matthias Wapler 2
Medical Physics, University Medical Center
Freiburg, Freiburg, Germany,
for Microsystems Engineering IMTEK, University of
Freiburg, Freiburg, Germany
Magnetic resonance microscopy allows resolving
structures smaller than 100
It is used to image for example organotypic slice
cultures. However, the identification of specific
microstructural elements is performed by
light-microscopy based correlative histology techniques.
MR image artefacts because of susceptibility effects,
motion or sample preparation during staining can lead to
discrepancies, impairing the comparison between images
from both modalities. In this work an optical microscope
was built to fit in an ultra-high field small animal
scanner for simultaneous optical microscopy and magnetic
resonance experiments. First successful concurrent and
mutually unaffected optical microscopy and magnetic
resonance experiments are presented.
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