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Abstract #0408

Concurrent Optical and Magnetic Resonance Microscopy

Frederik Testud 1 , Elmar Fischer 1 , Katharina Gbel 1 , Nils Spengler 2 , Ulrike Wallrabe 2 , Maxim Zaitsev 1 , and Matthias Wapler 2

1 Medical Physics, University Medical Center Freiburg, Freiburg, Germany, 2 Department for Microsystems Engineering IMTEK, University of Freiburg, Freiburg, Germany

Magnetic resonance microscopy allows resolving structures smaller than 100 lower case Greek mu m. It is used to image for example organotypic slice cultures. However, the identification of specific microstructural elements is performed by light-microscopy based correlative histology techniques. MR image artefacts because of susceptibility effects, motion or sample preparation during staining can lead to discrepancies, impairing the comparison between images from both modalities. In this work an optical microscope was built to fit in an ultra-high field small animal scanner for simultaneous optical microscopy and magnetic resonance experiments. First successful concurrent and mutually unaffected optical microscopy and magnetic resonance experiments are presented.

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