Abstract #0411
Continuous Bone Density Measurement for Simultaneous MR-PET Attenuation Correction using Water- and Fat-Suppressed Projection Imaging (WASPI)
Chuan Huang 1,2 , Jinsong Ouyang 1 , Timothy Reese 3 , Yaotang Wu 4 , Georges El Fakhri 1 , and Jerome Ackerman 3
1
Center for Advanced Medical Imaging
Sciences, Radiology, Massachusetts General Hospital,
Boston, MA, United States,
2
Research
Radiology, Psychiatry, Stony Brook Medicine, Stony
Brook, NY, United States,
3
Martinos
Center for Biomedical Imaging, Radiology, Massachusetts
General Hospital, Boston, MA, United States,
4
Radiology,
Children's Hospital Boston, Boston, MA, United States
Simultaneous MR-PET is an emerging hybrid modality that
is attracting substantial interest. Currently, one of
the hurdles for MR-PET is its quantitative accuracy due
to challenges in obtaining accurate attenuation
correction. For MR-PET, the PET attenuation map
typically needs to be derived from the MR images. The
standard approach is to segment an MR image volume into
different tissue classes and then assign the
corresponding attenuation coefficients to them. Accurate
attenuation correction in regions within or near bone is
still an open problem due to lack of signal from solid
bone in most MR sequences. Investigators have proposed
to use atlas-based maps and the ultrashort echo time
(UTE) pulse sequence to identify bones. These approaches
do not take into account the intra- and inter-patient
bone density variations and may lead to bias in the
quantitation. In this work, we investigated the
possibility of using the Water- And fat-Suppressed
Proton projection Imaging (WASPI) sequence to measure
bone density.
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