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Abstract #0411

Continuous Bone Density Measurement for Simultaneous MR-PET Attenuation Correction using Water- and Fat-Suppressed Projection Imaging (WASPI)

Chuan Huang 1,2 , Jinsong Ouyang 1 , Timothy Reese 3 , Yaotang Wu 4 , Georges El Fakhri 1 , and Jerome Ackerman 3

1 Center for Advanced Medical Imaging Sciences, Radiology, Massachusetts General Hospital, Boston, MA, United States, 2 Research Radiology, Psychiatry, Stony Brook Medicine, Stony Brook, NY, United States, 3 Martinos Center for Biomedical Imaging, Radiology, Massachusetts General Hospital, Boston, MA, United States, 4 Radiology, Children's Hospital Boston, Boston, MA, United States

Simultaneous MR-PET is an emerging hybrid modality that is attracting substantial interest. Currently, one of the hurdles for MR-PET is its quantitative accuracy due to challenges in obtaining accurate attenuation correction. For MR-PET, the PET attenuation map typically needs to be derived from the MR images. The standard approach is to segment an MR image volume into different tissue classes and then assign the corresponding attenuation coefficients to them. Accurate attenuation correction in regions within or near bone is still an open problem due to lack of signal from solid bone in most MR sequences. Investigators have proposed to use atlas-based maps and the ultrashort echo time (UTE) pulse sequence to identify bones. These approaches do not take into account the intra- and inter-patient bone density variations and may lead to bias in the quantitation. In this work, we investigated the possibility of using the Water- And fat-Suppressed Proton projection Imaging (WASPI) sequence to measure bone density.

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