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Abstract #0432

Topology of structural connectomes in healthy carriers of common gene variants associated with schizophrenia

Mark Drakesmith 1,2 , Thomas Lancaster 2 , Sonya Foley 1,2 , Lisa Brindley 1,2 , Derek K Jones 1,2 , and David Linden 1,2

1 CUBRIC, Cardiff University, Cardiff, Wales, United Kingdom, 2 Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff, Wales, United Kingdom

Graph theory has been used to explore the topology of structural connectomes in psychiatric illnesses. However, no studies have yet looked at topology in carriers of high-risk genotypes. Here, the effects of two common schizophrenia-risk SNPs, ZNF804A and CACNA1C, on network topology are examined in 85 healthy participants. Results show differences similar to schizophrenia in carriers of the high-risk allele of CACNA1C and several regional deficits, including the precuneus, a core network hub. These differences may be due to downstream effects of synaptic dysfunction. This study is the first to show topological network differences in healthy carriers of high-risk genotypes.

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