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Abstract #0434

GluCEST in the olfactory cortex as a marker of heightened clinical risk for schizophrenia

Ravi Prakash Reddy Nanga 1 , David R. Roalf 2 , Hari Hariharan 1 , Mark A. Elliott 1 , Karthik Prabhakaran 2 , Megan Quarmley 2 , Paul J. Moberg 2 , Ravinder Reddy 1 , and Bruce I. Turetsky 2

1 Radiology, University of Pennsylvania Health Systems, Philadelphia, Pennsylvania, United States, 2 Psychiatry, University of Pennsylvania, Philadelphia, Pennsylvania, United States

In vivo measurement of glutamate neurotransmitter levels in brain structures implicated in neuropsychiatry disorders may provide insight into the role of these structures play in the manifestation of symptoms and potentially lead to improvements in therapy. Recent, studies with methods based on glutamate chemical exchange saturation transfer (GluCEST) in animal models and humans suggest that GluCEST mapping may serve as a biomarker of brain glutamate distribution, in vivo. Here, we use GluCEST to map glutamate distributions, within olfactory cortex, in healthy individuals (HC) and individuals at clinical risk for developing schizophrenia (CR).

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