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Abstract #0450

Reproducibility of Phase-Contrast MRI in the Coronary Artery: Towards Noninvasive Pressure Gradient Measurement and Quantification of Fractional Flow Reserve

Zixin Deng 1,2 , Yang Qi 2 , Xiaoming Bi 3 , Zhaoyang Fan 2 , and Debiao Li 1,2

1 Bioengineering, University of California, Los Angeles, Los Angeles, California, United States, 2 Biomedical Imaging Research Institute (BIRI), Cedars-Sinai Medical Center, Los Angeles, California, United States, 3 R&D, Siemens Healthcare, Los Angeles, California, United States

Fractional Flow Reserve (FFR) invasively evaluates the functional severity of an intermediate stenosis by measuring the stenotic pressure drop via catheterization. Noninvasive pressure measurements using PC-MRI and Navier-Stokes equations have been shown in the aorta, carotid and renal arteries. In this study, the feasibility and reproducibility of PC-MRI and noninvasive pressure calculations were evaluated in the coronary arteries to establish the robustness of noninvasive FFR measurement using MRI. Excellent correlations were observed in the through-plane and slightly lower in the in-plane velocities between the repeated acquisitions. The noninvasive pressure values in healthy subjects were near zero, as expected.

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