Abstract #0476
Microscopic diffusion anisotropy imaging: An ex-vivo hypomyelination mouse study
Enrico Kaden 1 , Nathaniel D Kelm 2 , Robert P Carson 3 , Mark D Does 2 , and Daniel C Alexander 1
1
Centre for Medical Image Computing,
University College London, London, United Kingdom,
2
Institute
of Imaging Science, Vanderbilt University, Nashville,
TN, United States,
3
Departments
of Neurology and Pediatrics, Vanderbilt University,
Nashville, TN, United States
This work proposes a new method, which we call spherical
mean technique (SMT), for estimating the microscopic
diffusion anisotropy unconfounded by neurite orientation
dispersion and crossing, which are ubiquitous in the
brain. A distinguishing feature of the method is that it
does not rely on complex diffusion sequences with
multiple gradient pulses or magic-angle spinning. We
will demonstrate SMT in an ex-vivo mouse brain study and
its capability for detecting hypomyelination conditions.
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