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Abstract #0476

Microscopic diffusion anisotropy imaging: An ex-vivo hypomyelination mouse study

Enrico Kaden 1 , Nathaniel D Kelm 2 , Robert P Carson 3 , Mark D Does 2 , and Daniel C Alexander 1

1 Centre for Medical Image Computing, University College London, London, United Kingdom, 2 Institute of Imaging Science, Vanderbilt University, Nashville, TN, United States, 3 Departments of Neurology and Pediatrics, Vanderbilt University, Nashville, TN, United States

This work proposes a new method, which we call spherical mean technique (SMT), for estimating the microscopic diffusion anisotropy unconfounded by neurite orientation dispersion and crossing, which are ubiquitous in the brain. A distinguishing feature of the method is that it does not rely on complex diffusion sequences with multiple gradient pulses or magic-angle spinning. We will demonstrate SMT in an ex-vivo mouse brain study and its capability for detecting hypomyelination conditions.

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