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Abstract #0487

Simultaneous Measurement of DSC- and DCE-MRI Parameters using Dual-Echo Spiral with a Standard Dose of Gadolinium in Comparison to Single-Echo GRE-EPI Methods in Brain Tumors

Kathleen M Schmainda 1 , Melissa Prah 2 , Leslie C Baxter 3 , Eric S Paulson 4 , Sharmeen Maze 3 , James Pipe 3 , Dingui Wang 3 , Josef Debbins 3 , and Leland Hu 5

1 Radiology, Medical College of Wisconsin, Milwaukee, WI, United States, 2 Radiology, Medical College of Wisconsin, WI, United States, 3 Barrow Neurological Institute, Phoenix, AZ, United States, 4 Medical College of Wisconsin, WI, United States, 5 Mayo Clinic, Scottsdale, AZ, United States

Previously the dual-echo gradient-echo spiral-based (DEGES) method proved to be one of the most accurate for the determination of relative cerebral blood volume (rCBV) values in brain tumors. The DEGES method also enables the simultaneous collection of DSC and DCE (dynamic contrast enhanced) data, all with just a single dose of gadolinium (Gd) contrast agent. This study demonstrates that DEGES provides results equivalent to those obtained with the more proven GRE-EPI DSC MRI methods. This motivates a more widespread evaluation and adoption of this approach for the collection of multiparameter perfusion data in brain tumors.

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