Abstract #0487
Simultaneous Measurement of DSC- and DCE-MRI Parameters using Dual-Echo Spiral with a Standard Dose of Gadolinium in Comparison to Single-Echo GRE-EPI Methods in Brain Tumors
Kathleen M Schmainda 1 , Melissa Prah 2 , Leslie C Baxter 3 , Eric S Paulson 4 , Sharmeen Maze 3 , James Pipe 3 , Dingui Wang 3 , Josef Debbins 3 , and Leland Hu 5
1
Radiology, Medical College of Wisconsin,
Milwaukee, WI, United States,
2
Radiology,
Medical College of Wisconsin, WI, United States,
3
Barrow
Neurological Institute, Phoenix, AZ, United States,
4
Medical
College of Wisconsin, WI, United States,
5
Mayo
Clinic, Scottsdale, AZ, United States
Previously the dual-echo gradient-echo spiral-based
(DEGES) method proved to be one of the most accurate for
the determination of relative cerebral blood volume
(rCBV) values in brain tumors. The DEGES method also
enables the simultaneous collection of DSC and DCE
(dynamic contrast enhanced) data, all with just a single
dose of gadolinium (Gd) contrast agent. This study
demonstrates that DEGES provides results equivalent to
those obtained with the more proven GRE-EPI DSC MRI
methods. This motivates a more widespread evaluation and
adoption of this approach for the collection of
multiparameter perfusion data in brain tumors.
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