Meeting Banner
Abstract #0509

White Matter Tract Integrity, Amyloid burden and Structural atrophy in normal aging and Mild Cognitive Impairment: a PET-MRI study.

Ileana O. Jelescu 1 , Timothy M. Shepherd 1 , Dmitry S. Novikov 1 , Yu-Shin Ding 1 , Thomas Koesters 1 , Kent P. Friedman 1 , Jacqueline Smith 1 , James E. Galvin 2 , and Els Fieremans 1

1 Center for Biomedical Imaging, Dept. of Radiology, NYU Langone Medical Center, New York, New York, United States, 2 Alzheimer Disease Center, Depts. of Neurology, Psychiatry and Population Health, NYU Langone Medical Center, New York, New York, United States

Along with cortical abnormalities, white matter (WM) microstructural changes are involved in the pathogenesis of AD. We estimate WM Tract Integrity (WMTI) metrics derived from diffusion kurtosis imaging (DKI) in normal aging and amnestic Mild Cognitive Impairment (aMCI). DKI and WMTI metrics in WM ROIs spatially connected to the hippocampus and cortex and/or known to be affected in AD correlate significantly with transverse measurements of pathology such as hippocampal atrophy and amyloid burden. Future work will focus on the chronology of changes (i.e. whether the earliest changes take place in the cortex, in the WM or in sub-cortical structures).

This abstract and the presentation materials are available to members only; a login is required.

Join Here