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Abstract #0512

Effects of Real-time fMRI Neurofeedback of the Amygdala Specific to Major Depressive Disorder

Vadim Zotev 1 , Kymberly D. Young 1 , Raquel Phillips 1 , Masaya Misaki 1 , and Jerzy Bodurka 1,2

1 Laureate Institute for Brain Research, Tulsa, OK, United States, 2 College of Engineering, University of Oklahoma, Tulsa, OK, United States

We have investigated effects of real-time fMRI neurofeedback (rtfMRI-nf) targeting the left amygdala (LA) to identify changes in LA functional connectivity that correlate with depression severity (HDRS). Thirteen MDD patients learned to upregulate their LA activity using rtfMRI-nf during a positive emotion induction task based on retrieval of happy autobiographical memories. We observed a significant positive correlation between the LA connectivity enhancement across rtfMRI-nf runs and HDRS for several key brain regions including the rostral anterior cingulate cortex (rACC) and mediodorsal thalamus. Our results suggest that rtfMRI-nf holds ability to correct the LA functional connectivity impairments specific to MDD.

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