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Abstract #0514

Effect of Repetitive Transcranial Magnetic Stimulation on fMRI Resting-State Connectivity in Multiple System Atrophy

Ying-hui Chou 1 , Hui You 2 , Han Wang 2 , Yan-Ping Zhao 2 , Bo Hou 2 , Nan-kuei Chen 1 , and Feng Feng 2

1 Duke Brain Imaging and Analysis Center, Durham, NC, United States, 2 Peking Union Medical College Hospital, Beijing, China

In this study, we demonstrated that 10-session 5-Hz repetitive transcranial magnetic stimulation (rTMS) targeting at the left primary motor area could be used to improve motor function in patients with Multiple System Atrophy (MSA). The improvement of motor function was accompanied by increases in resting-state functional connectivity associated with the default mode network. Our findings shed light on the clinical utility of the rTMS technique, and the identification of rTMS- and symptoms-related functional networks may generate new insights into future therapeutic candidate for patients with MSA.

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